Anti-CASP9 Polyclonal Antibody - HRP
Cat: K108570P - HRP
Summary:
| 【Product name】：Anti-CASP9 Polyclonal Antibody - HRP | 【Source】：Rabbit |
| 【Isotype】：IgG | |
| 【Gene ID】：842 | 【Swiss Prot】：P55211 |
| 【Species reactivity】：Human,Rat,Mouse | |
| 【Tested applications】：IHC | |
| 【Recommended dilution】：WB 1:500-2000. ELISA 1:100-1000. IHC 1:20-200. ICC 1:50-200 | |
| 【Immunogen】：A synthetic peptide of Human CASP9 | |
| 【Storage】：Store at -20℃, avoid freeze/thaw cycles. | |
Background:
Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP).Isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9.
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