Anti-COMP Polyclonal Antibody
Cat: K004228P
Summary:
| 【Product name】：Anti-COMP Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | |
| 【Gene ID】：1311 | 【Swiss Prot】：P49747 |
| 【Species reactivity】：Human,Mouse,Rat | |
| 【Tested applications】：IF,WB | |
| 【Immunogen】：Recombinant protein of human COMP | |
| 【Storage】：Store at -20℃, avoid freeze/thaw cycles. | |
Background:
The protein encoded by this gene is a noncollagenous extracellular matrix (ECM) protein. It consists of five identical glycoprotein subunits, each with EGF-like and calcium-binding (thrombospondin-like) domains. Oligomerization results from formation of a five-stranded coiled coil and disulfides. Binding to other ECM proteins such as collagen appears to depend on divalent cations. Contraction or expansion of a 5 aa aspartate repeat and other mutations can cause pseudochondroplasia (PSACH) and multiple epiphyseal dysplasia (MED).
Verified picture:
Western blot analysis with COMP antibody diluted at 1:1000;Lane: SKOV3 U2OS.
Immunofluorescence analysis of Rat cartilage using COMP antibody diluted at 1:50.