Anti-CD95/FAS Polyclonal Antibody - SAlexa Fluor 633
Cat: K009462P - SAlexa Fluor 633
Summary:
| 【Product name】：Anti-CD95/FAS Polyclonal Antibody - SAlexa Fluor 633 | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：246097 | 【Swiss Prot】：Q63199 |
| 【Tested applications】：ELISA,IF,IHC | |
| 【Recommended dilution】：ELISA 1:5000-10000. IHC 1:100-500. IF 1:100-500. | |
| 【Immunogen】：A synthetic peptide of rat FAS | |
| 【Public Immunogen Range】：35-110/327aa | |
| 【Storage】：Store at -20℃. Avoid freeze / thaw cycles. | |
Background:
Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro).
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