Anti-DVL1 Polyclonal Antibody
Cat: K009492P
Summary:
| 【Product name】：Anti-DVL1 Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | |
| 【Gene ID】：1855 | 【Swiss Prot】：O14640 |
| 【Species reactivity】：Human,Rat,Mouse | |
| 【Tested applications】：ELISA,IF,IHC,WB | |
| 【Immunogen】：A synthetic peptide of human DVL1 | |
| 【Storage】：Store at -20℃. Avoid freeze / thaw cycles. | |
Background:
Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ).
Verified picture:
Western blot analysis with DVL1 antibody diluted at 1:1000;Lane: Mouse Testis NIH/3T3.
Immunohistochemistry of paraffin-embedded Human cervical carcinoma with DVL1 antibody diluted at 1:200
Immunohistochemistry of paraffin-embedded Rat brain with DVL1 antibody diluted at 1:400.