Anti-Collagen IV Polyclonal Antibody
Cat: K009506P
Summary:
| 【Product name】：Anti-Collagen IV Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：1282 | 【Swiss Prot】：P02462 |
| 【Tested applications】：WB,IHC,IF,ELISA,FCM | |
| 【Recommended dilution】：WB 1:500-2000. ELISA 1:5000-10000. IHC 1:100-500. FCM 1μg/Test. IF 1:100-500. | |
| 【Immunogen】：A synthetic peptide of human Collagen IV | |
| 【Public Immunogen Range】：1401-1500/1669aa | |
| 【Storage】：Store at -20℃. Avoid freeze / thaw cycles. | |
Background:
Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. Arresten, comprising the C-terminal NC1 domain, inhibits angiogenesis and tumor formation. The C-terminal half is found to possess the anti-angiogenic activity. Specifically inhibits endothelial cell proliferation, migration and tube formation. Inhibits expression of hypoxia-inducible factor 1alpha and ERK1/2 and p38 MAPK activation. Ligand for alpha1/beta1 integrin.
Verified picture:
Immunohistochemistry of paraffin-embedded Rabbit cartilage tissue with Collagen IV antibody diluted at 1:200