Anti-Collagen IV Polyclonal Antibody - SAlexa Fluor 350
Cat: K009506P - SAlexa Fluor 350
Summary:
| 【Product name】：Anti-Collagen IV Polyclonal Antibody - SAlexa Fluor 350 | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：1282 | 【Swiss Prot】：P02462 |
| 【Tested applications】：ICC IF | |
| 【Recommended dilution】：ICC 1:50-200. IF 1:50-200 | |
| 【Immunogen】：A synthetic peptide of human Collagen IV | |
| 【Public Immunogen Range】：1401-1500/1669aa | |
| 【Storage】：Store at -20℃. Avoid freeze / thaw cycles. | |
Background:
Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. Arresten, comprising the C-terminal NC1 domain, inhibits angiogenesis and tumor formation. The C-terminal half is found to possess the anti-angiogenic activity. Specifically inhibits endothelial cell proliferation, migration and tube formation. Inhibits expression of hypoxia-inducible factor 1alpha and ERK1/2 and p38 MAPK activation. Ligand for alpha1/beta1 integrin.
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