下载
Anti-RELA Polyclonal Antibody - SAlexa Fluor 405
Cat: K009537P - SAlexa Fluor 405
Summary:
【Product name】:Anti-RELA Polyclonal Antibody - SAlexa Fluor 405 【Source】:Rabbit
【Isotype】:IgG
【Gene ID】:5970 【Swiss Prot】:Q04206
【Species reactivity】:Rat,Mouse,Human
【Tested applications】:ELISA,FCM,IF,ICC,IHC,WB
【Immunogen】:A synthetic peptide of human RELA
【Storage】:Store at -20℃. Avoid freeze / thaw cycles.
Background:
NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepre
Verified picture: