Anti-DKK1 Polyclonal Antibody - HRP
Cat: K009546P - HRP
Summary:
| 【Product name】：Anti-DKK1 Polyclonal Antibody - HRP | 【Source】：Rabbit |
| 【Isotype】：IgG | |
| 【Gene ID】：22943 | 【Swiss Prot】：O94907 |
| 【Species reactivity】：Dog | |
| 【Tested applications】：ELISA,IF,IHC | |
| 【Recommended dilution】：WB 1:500-2000. ELISA 1:100-1000. IHC 1:20-200. ICC 1:50-200 | |
| 【Immunogen】：A synthetic peptide of human DKK1 | |
| 【Storage】：Store at -20℃. Avoid freeze / thaw cycles. | |
Background:
Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
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