Anti-CASP3 Polyclonal Antibody
Cat: K009567P
Summary:
| 【Product name】：Anti-CASP3 Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | |
| 【Gene ID】：836 | 【Swiss Prot】：P42574 |
| 【Species reactivity】：Rat,Mouse,Human | |
| 【Tested applications】：ELISA,FCM,IF,IHC,WB | |
| 【Immunogen】：A synthetic peptide of human CASP3 | |
| 【Storage】：Store at -20℃. Avoid freeze / thaw cycles. | |
Background:
Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.
Verified picture:
Western blot analysis with Caspase 3 precursor antibody diluted at 1:1000;Lane: Mouse Spleen Mouse Lung.
Immunohistochemistry of paraffin-embedded Rat brain with CASP3 antibody diluted at 1:200
Immunohistochemistry of paraffin-embedded rat brain tissue with Caspase 3 precursor antibody diluted at 1:200.