Anti-phospho-STAT3(Ser727) Polyclonal Antibody
Cat: K009598P
Summary:
| 【Product name】：Anti-phospho-STAT3(Ser727) Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：6774 | 【Swiss Prot】：P40763 |
| 【Tested applications】：ELISA,FCM,IF,IHC | |
| 【Recommended dilution】：ELISA 1:5000-10000. IHC 1:100-500. FCM 0.2μg /Test. IF 1:100-500. | |
| 【Immunogen】：A synthetic peptide of human STAT3 around the phosphorylation site of Ser727 | |
| 【Storage】：Store at -20℃. Avoid freeze / thaw cycles. | |
Background:
Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA. Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity. Plays an important role in host defense in methicillin-resistant S.aureus lung infection by regulating the expression of the antimicrobial lectin REG3G (By similarity).
Verified picture:
Immunohistochemistry of paraffin-embedded Rat heart with phospho-STAT3(Ser727) antibody diluted at 1:200
Immunohistochemistry of paraffin-embedded rat heart with phospho-STAT3 (Ser727) antibody diluted at 1:200.