Anti-PHD2 Polyclonal Antibody - SAlexa Fluor 750
Cat: K009608P - SAlexa Fluor 750
Summary:
| 【Product name】：Anti-PHD2 Polyclonal Antibody - SAlexa Fluor 750 | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：54583 | 【Swiss Prot】：Q9GZT9 |
| 【Tested applications】：WB,ELISA,IF,IHC | |
| 【Recommended dilution】：WB 1:500-2000. ELISA 1:5000-10000. IHC 1:100-500. IF 1:100-500. | |
| 【Immunogen】：A synthetic peptide of human PHD2 | |
| 【Public Immunogen Range】：42-140/426aa | |
| 【Storage】：Store at -20℃. Avoid freeze / thaw cycles. | |
Background:
PHD2 protein catalyzes the posttranslational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. In the presence of oxygen, PHD2 converts specific prolyl residues in HIF alpha to hydroxyproline, leading to HIF alpha proteasomal degradation via the von Hippel-Lindau ubiquitylation complex. Low oxygen levels, sensed at the cellular level, cause the HIF conversion to be reduced so that HIF levels are stable. This results in increased angiogenesis as HIF1 alpha regulates the expression of many angiogenesis-related genes.
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