Anti-ANGPT2 Polyclonal Antibody
Cat: K009711P
Summary:
| 【Product name】：Anti-ANGPT2 Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | |
| 【Gene ID】：285 | 【Swiss Prot】：O15123 |
| 【Species reactivity】：Human | |
| 【Tested applications】：ELISA,IF,IHC,WB | |
| 【Immunogen】：A synthetic peptide of human ANGPT2 | |
| 【Storage】：Store at -20℃. Avoid freeze / thaw cycles. | |
Background:
Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal.
Verified picture:
Western blot analysis with Angiopoietin 2 antibody diluted at 1:300;Lane: HepG2.
Immunohistochemistry of paraffin-embedded human colon cancer with Angiopoietin 2 antibody diluted at 1:500.