Anti-ANGPT2 Polyclonal Antibody - SAlexa Fluor 532
Cat: K009711P - SAlexa Fluor 532
Summary:
| 【Product name】：Anti-ANGPT2 Polyclonal Antibody - SAlexa Fluor 532 | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：285 | 【Swiss Prot】：O15123 |
| 【Tested applications】：WB,IF,IHC,ELISA | |
| 【Recommended dilution】：WB 1:500-2000. ELISA 1:5000-10000. IHC 1:100-500. IF 1:100-500. | |
| 【Immunogen】：A synthetic peptide of human ANGPT2 | |
| 【Public Immunogen Range】：401-496/496aa | |
| 【Storage】：Store at -20℃. Avoid freeze / thaw cycles. | |
Background:
Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal.
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