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Anti-CTTN Polyclonal Antibody
Cat: K108992P
Summary:
【Product name】:Anti-CTTN Polyclonal Antibody 【Source】:Rabbit
【Isotype】:IgG
【Gene ID】:2017 【Swiss Prot】:Q14247
【Species reactivity】:Human
【Tested applications】:WB,IHC
【Immunogen】:A synthetic peptide of human CTTN
【Storage】:Store at -20℃, avoid freeze/thaw cycles.
Background:
This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene.
Verified picture:
Immunohistochemistry of paraffin-embedded Human pancreatic cancer with CTTN antibody diluted at 1:40
Western blot analysis with CTTN antibody diluted at 1:4000;Lane: Mouse kidney,Rat kidney