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Anti-Mki67 Polyclonal Antibody - SAlexa Fluor 405
Cat: K009725P - SAlexa Fluor 405
Summary:
【Product name】:Anti-Mki67 Polyclonal Antibody - SAlexa Fluor 405 【Source】:Rabbit
【Isotype】:IgG
【Gene ID】:17345 【Swiss Prot】:E9PVX6
【Species reactivity】:Rat,Mouse
【Tested applications】:IF,IHC
【Immunogen】:A synthetic peptide of mouse Ki67
【Storage】:Store at -20℃, avoid freeze/thaw cycles.
Background:
Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). Associates with the surface of the mitotic chromosome, the perichromosomal layer, and covers a substantial fraction of the chromosome surface (PubMed:27362226). Prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (By similarity). Does not contribute to the internal structure of mitotic chromosomes (PubMed:26949251). May play a role in chromatin organization (PubMed:26949251). It is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in maintaining mitotic chromosomes dispersed.
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