Anti-Active CASP3 Monoclonal Antibody - HRP
Cat: K200074M - HRP
Summary:
| 【Product name】：Anti-Active CASP3 Monoclonal Antibody - HRP | 【Source】：Mouse |
| 【Isotype】：IgG1 | |
| 【Gene ID】：836 | 【Swiss Prot】：P42574 |
| 【Species reactivity】：Human,Rat,Mouse | |
| 【Tested applications】：WB,IHC | |
| 【Recommended dilution】：WB 1:500-2000. ELISA 1:100-1000. IHC 1:20-200. ICC 1:50-200 | |
| 【Immunogen】：Recombinant Protein | |
| 【Storage】：Store at -20℃, avoid freeze/thaw cycles. | |
Background:
Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.
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