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Anti-TEAD2 Polyclonal Antibody
Cat: K109196P
Summary:
【Product name】:Anti-TEAD2 Polyclonal Antibody 【Source】:Rabbit
【Isotype】:IgG
【Gene ID】:8463 【Swiss Prot】:Q15562
【Species reactivity】:Human,Mouse
【Tested applications】:WB
【Immunogen】:A synthetic peptide of human TEAD2
【Storage】:Store at -20℃, avoid freeze/thaw cycles.
Background:
Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3'). May be involved in the gene regulation of neural development. Binds to the M-CAT motif.
Verified picture:
Western blot analysis with TEAD2 antibody diluted at 1:2000;Lane: HUVEC,SH-SY5Y,NIH3T3,C2C12