Anti-CALR Polyclonal Antibody
Cat: K109290P
Summary:
| 【Product name】：Anti-CALR Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | |
| 【Gene ID】：811 | 【Swiss Prot】：P27797 |
| 【Species reactivity】：Human,Rat,Mouse | |
| 【Tested applications】：WB,IF,IHC | |
| 【Immunogen】：Recombinant protein of human CALR | |
| 【Storage】：Store at -20℃, avoid freeze/thaw cycles. | |
Background:
CALR,also named as grp60, ERp60, HACBP, CRP55, CRTC and Calregulin, belongs to the calreticulin family. It is a molecular calcium-binding chaperone promoting folding, oligomeric assembly and quality control in the ER via the calreticulin/calnexin cycle. CALR is a ER marker. It interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. CALR interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export. The MW of CALR migrates aberrantly at 55 kDa by SDS-PAGE. Some study provided that it's a new possibility for CRT-mediated tumor immune prevention and treatment.
Verified picture:
Immunohistochemistry of paraffin-embedded Human prostate cancer using CALR antibody diluted at 1:100.
Western blot analysis with CALR antibody diluted at 1:2000;Lane: HepG2,293T,HL-60,HeLa,Kidney cancer,Mouse liver.
Immunofluorescence analysis of SH-SY5Y cells using CALR antibody diluted at 1:100.