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Anti-OPRK1 Polyclonal Antibody - SAlexa Fluor 488
Cat: K109389P - SAlexa Fluor 488
Summary:
【Product name】:Anti-OPRK1 Polyclonal Antibody - SAlexa Fluor 488 【Source】:Rabbit
【Isotype】:IgG
【Gene ID】:4986 【Swiss Prot】:P41145
【Species reactivity】:Human,Rat,Mouse
【Tested applications】:FC ICC IF
【Recommended dilution】:Flow-Cyt 1:50-200. ICC 1:50-200. IF 1:50-200
【Immunogen】:A synthetic peptide of human OPRK1
【Storage】:Store at -20℃, avoid freeze/thaw cycles.
Background:
G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions.
Verified picture: