Anti-JPT1 Polyclonal Antibody
Cat: K109456P
Summary:
| 【Product name】：Anti-JPT1 Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：51155 | 【Swiss Prot】：Q9UK76 |
| 【Tested applications】：WB | |
| 【Recommended dilution】：WB 1:500-2000. | |
| 【Immunogen】：A synthetic peptide of human JPT1 | |
| 【Public Immunogen Range】：25-75/154aa | |
| 【Storage】：Store at -20℃. Avoid freeze/thaw cycles. | |
Background:
Modulates negatively AKT-mediated GSK3B signaling. Induces CTNNB1 'Ser-33' phosphorylation and degradation through the suppression of the inhibitory 'Ser-9' phosphorylation of GSK3B, which represses the function of the APC:CTNNB1:GSK3B complex and the interaction with CDH1/E-cadherin in adherent junctions. Plays a role in the regulation of cell cycle and cell adhesion. Has an inhibitory role on AR-signaling pathway through the induction of receptor proteosomal degradation.
Verified picture:
Western blot analysis with JPT1 antibody diluted at 1:2000;Lane: Hela,NIH3T3,Mouse heart.