Anti-ALKBH4 Polyclonal Antibody - SAlexa Fluor 488
Cat: K109507P - SAlexa Fluor 488
Summary:
| 【Product name】：Anti-ALKBH4 Polyclonal Antibody - SAlexa Fluor 488 | 【Source】：Rabbit |
| 【Isotype】：IgG | |
| 【Gene ID】：54784 | 【Swiss Prot】：Q9NXW9 |
| 【Species reactivity】：Human,Mouse | |
| 【Tested applications】：FC ICC IF | |
| 【Recommended dilution】：Flow-Cyt 1:50-200. ICC 1:50-200. IF 1:50-200 | |
| 【Immunogen】：Recombinant protein of human ALKBH4 | |
| 【Storage】：Store at -20℃, avoid freeze/thaw cycles. | |
Background:
Dioxygenase that mediates demethylation of actin monomethylated at 'Lys-84' (K84me1), thereby acting as a regulator of actomyosin-processes (PubMed:23673617). Demethylation of actin K84me1 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration (PubMed:23673617). In addition to proteins, also demethylates DNA: specifically demethylates DNA methylated on the 6th position of adenine (N6-methyladenosine) DNA, thereby regulating Polycomb silencing (By similarity).
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