Anti-BAG3 Polyclonal Antibody
Cat: K109754P
Summary:
| 【Product name】：Anti-BAG3 Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | |
| 【Gene ID】：9531 | 【Swiss Prot】：O95817 |
| 【Species reactivity】：Human,Rat,Mouse | |
| 【Tested applications】：WB | |
| 【Immunogen】：Recombinant protein of Human BAG3 | |
| 【Storage】：Store at -20℃, avoid freeze/thaw cycles. | |
Background:
Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70. Has anti-apoptotic activity. Plays a role in the HSF1 nucleocytoplasmic transport.
Verified picture:
Western blot analysis with BAG3 antibody diluted at 1:2000;Lane:HeLa,MCF7