Anti-VCL Polyclonal Antibody
Cat: K110119P
Summary:
| 【Product name】：Anti-VCL Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Octanoic acid-ammonium sulfate precipitation |
| 【Gene ID】：7414 | 【Swiss Prot】：P18206 |
| 【Tested applications】：WB,IHC | |
| 【Recommended dilution】：IHC 1:100-300. IF 1:50-200. | |
| 【Immunogen】：Recombinant protein of human VCL | |
| 【Public Immunogen Range】：1-350aa | |
| 【Storage】：Store at -20℃. Avoid freeze/thaw cycles. | |
Background:
Vinculin is a cytoskeletal protein associated with cell-cell and cell-matrix junctions, where it is thought to function as one of several interacting proteins involved in anchoring F-actin to the membrane. Defects in VCL are the cause of cardiomyopathy dilated type 1W. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined.
Verified picture:
Immunohistochemistry of paraffin-embedded Human pancreatic cancer with VCL antibody diluted at 1:200