Anti-CASP10 Polyclonal Antibody - SAlexa Fluor 640
Cat: K110451P - SAlexa Fluor 640
Summary:
| 【Product name】：Anti-CASP10 Polyclonal Antibody - SAlexa Fluor 640 | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：843 | 【Swiss Prot】：Q92851 |
| 【Tested applications】：IHC | |
| 【Recommended dilution】：IHC 1:100-300. | |
| 【Immunogen】：A synthetic peptide of human CASP10 | |
| 【Public Immunogen Range】：205-255/521aa | |
| 【Storage】：Store at -20℃. Avoid freeze/thaw cycles. | |
Background:
Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates caspase-3, -4, -6, -7, -8, and -9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp-|-AMC and Asp-Glu-Val-Asp-|-AMC.1 Publication Isoform 7 can enhance NF-kappaB activity but promotes only slight apoptosis.Isoform C is proteolytically inactive.
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