Anti-NFE2L2 Polyclonal Antibody
Cat: K110575P
Summary:
| 【Product name】：Anti-NFE2L2 Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：4780 | 【Swiss Prot】：Q16236 |
| 【Tested applications】：IF,IHC,ELISA | |
| 【Recommended dilution】：IHC 1:100-300. IF 1:50-200. | |
| 【Immunogen】：Recombinant protein of human NFE2L2 | |
| 【Public Immunogen Range】：1-350aa | |
| 【Storage】：Store at -20℃. Avoid freeze/thaw cycles. | |
Background:
Transcription factor that plays a key role in the response to oxidative stress: binds to antioxidant response (ARE) elements present in the promoter region of many cytoprotective genes, such as phase 2 detoxifying enzymes, and promotes their expression, thereby neutralizing reactive electrophiles (PubMed:11035812, PubMed:19489739, PubMed:29018201, PubMed:31398338). In normal conditions, ubiquitinated and degraded in the cytoplasm by the BCR(KEAP1) complex (PubMed:11035812, PubMed:15601839, PubMed:29018201). In response to oxidative stress, electrophile metabolites inhibit activity of the BCR(KEAP1) complex, promoting nuclear accumulation of NFE2L2/NRF2, heterodimerization with one of the small Maf proteins and binding to ARE elements of cytoprotective target genes (PubMed:19489739, PubMed:29590092).
Verified picture:
Immunohistochemistry of paraffin-embedded Human renal cancer using NFE2L2 antibody diluted at 1:200