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Anti-GNL3L Polyclonal Antibody - HRP
Cat: K110672P - HRP
Summary:
【Product name】:Anti-GNL3L Polyclonal Antibody - HRP 【Source】:Rabbit
【Isotype】:IgG 【Purification】:Affinity purification
【Gene ID】:54552 【Swiss Prot】:Q9NVN8
【Tested applications】:IHC
【Recommended dilution】:WB 1:500-2000. ELISA 1:100-1000. IHC 1:20-200. ICC 1:50-200
【Immunogen】:A synthetic peptide of human GNL3L
【Public Immunogen Range】:1-51/582aa
【Storage】:Store at -20℃. Avoid freeze/thaw cycles.
Background:
Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis, promotes metaphase-to-anaphase transition. Stabilizes MDM2 protein by preventing its ubiquitination, and hence proteasomal degradation. By acting on MDM2, may affect TP53 activity. Required for normal processing of ribosomal pre-rRNA. Binds GTP.
Verified picture: