Anti-EIF4ENIF1 Polyclonal Antibody
Cat: K110735P
Summary:
| 【Product name】：Anti-EIF4ENIF1 Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Octanoic acid-ammonium sulfate precipitation |
| 【Gene ID】：56478 | 【Swiss Prot】：Q9NRA8 |
| 【Tested applications】：WB;IHC;IF,WB,IHC,IF | |
| 【Recommended dilution】：WB 1:1000-3000. IHC 1:100-300. IF 1:50-200. | |
| 【Immunogen】：Recombinant protein of human EIF4ENIF1 | |
| 【Public Immunogen Range】：1-350aa | |
| 【Storage】：Store at -20℃. Avoid freeze/thaw cycles. | |
Background:
EIF4E-binding protein that regulates translation and stability of mRNAs in processing bodies (P-bodies). Plays a key role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation (PubMed:24335285, PubMed:32354837). Acts as a binding platform for multiple RNA-binding proteins: promotes deadenylation of mRNAs via its interaction with the CCR4-NOT complex, and blocks decapping via interaction with eIF4E (EIF4E and EIF4E2), thereby protecting deadenylated and repressed mRNAs from degradation. Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis. Promotes miRNA-mediated translational repression. Required for the formation of P-bodies.
Verified picture:
Western blot analysis with EIF4ENIF1 antibody diluted at 1:2000;Lane:U-251,MCF7,Hela,HepG2,THP-1,LO2,293T,COS-7
Immunohistochemistry of paraffin-embedded Human colorectal cancer with EIF4ENIF1 antibody diluted at 1:200
Immunohistochemistry of paraffin-embedded Human endometrial cancer with EIF4ENIF1 antibody diluted at 1:200