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Anti-EIF4ENIF1 Polyclonal Antibody - SAlexa Fluor 633
Cat: K110735P - SAlexa Fluor 633
Summary:
【Product name】:Anti-EIF4ENIF1 Polyclonal Antibody - SAlexa Fluor 633 【Source】:Rabbit
【Isotype】:IgG 【Purification】:Octanoic acid-ammonium sulfate precipitation
【Gene ID】:56478 【Swiss Prot】:Q9NRA8
【Tested applications】:WB;IHC;IF,WB,IHC,IF
【Recommended dilution】:WB 1:1000-3000. IHC 1:100-300. IF 1:50-200.
【Immunogen】:Recombinant protein of human EIF4ENIF1
【Public Immunogen Range】:1-350aa
【Storage】:Store at -20℃. Avoid freeze/thaw cycles.
Background:
EIF4E-binding protein that regulates translation and stability of mRNAs in processing bodies (P-bodies). Plays a key role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation (PubMed:24335285, PubMed:32354837). Acts as a binding platform for multiple RNA-binding proteins: promotes deadenylation of mRNAs via its interaction with the CCR4-NOT complex, and blocks decapping via interaction with eIF4E (EIF4E and EIF4E2), thereby protecting deadenylated and repressed mRNAs from degradation. Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis. Promotes miRNA-mediated translational repression. Required for the formation of P-bodies.
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