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Anti-Bcl-6 Polyclonal Antibody - Biotin
Cat: K110855P - Biotin
Summary:
【Product name】:Anti-Bcl-6 Polyclonal Antibody - Biotin 【Source】:Rabbit
【Isotype】:IgG 【Purification】:Affinity purification
【Gene ID】:604 【Swiss Prot】:P41182
【Tested applications】:WB ELISA IHC ICC
【Recommended dilution】:WB 1:50-200. ELISA 1:100-1000. IHC 1:20-200. ICC 1:50-200. IF 1:50-200
【Immunogen】:A synthetic peptide of human Bcl-6
【Public Immunogen Range】:440-490/706aa
【Storage】:Store at -20℃. Avoid freeze/thaw cycles.
Background:
The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of STAT-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene.
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