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Anti-CDH3 Polyclonal Antibody
Cat: K111121P
Summary:
【Product name】:Anti-CDH3 Polyclonal Antibody 【Source】:Rabbit
【Isotype】:IgG 【Purification】:Affinity purification
【Gene ID】:1001 【Swiss Prot】:P22223
【Tested applications】:IHC
【Recommended dilution】:IHC 1:50-200.
【Immunogen】:A synthetic peptide of human CDH3
【Public Immunogen Range】:305-355/829aa
【Storage】:Store at -20℃. Avoid freeze/thaw cycles.
Background:
This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. This gene is located in a gene cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. In addition, aberrant expression of this protein is observed in cervical adenocarcinomas. Mutations in this gene are associated with hypotrichosis with juvenile macular dystrophy and ectodermal dysplasia, ectrodactyly, and macular dystrophy syndrome (EEMS).
Verified picture:
Immunohistochemistry of paraffin-embedded Human colorectal cancer with CDH3 antibody diluted at 1:100.
Immunohistochemistry of paraffin-embedded Human endometrial cancer with CDH3 antibody diluted at 1:100.