Anti-NEIL2 Polyclonal Antibody
Cat: K111355P
Summary:
| 【Product name】：Anti-NEIL2 Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：252969 | 【Swiss Prot】：Q969S2 |
| 【Tested applications】：WB | |
| 【Recommended dilution】：WB 1:1000-3000. | |
| 【Immunogen】：Recombinant protein of human NEIL2 | |
| 【Public Immunogen Range】：1-333aa | |
| 【Storage】：Store at -20℃. Avoid freeze/thaw cycles. | |
Background:
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Has DNA glycosylase activity towards 5-hydroxyuracil and other oxidized derivatives of cytosine with a preference for mismatched double-stranded DNA (DNA bubbles). Has low or no DNA glycosylase activity towards thymine glycol, 2-hydroxyadenine, hypoxanthine and 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
Verified picture:
Western blot analysis with NEIL2 antibody diluted at 1:2000;Lane: SHSY5Y.