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Anti-NOTCH1 Polyclonal Antibody
Cat: K111550P
Summary:
【Product name】:Anti-NOTCH1 Polyclonal Antibody 【Source】:Rabbit
【Isotype】:IgG 【Purification】:Affinity purification
【Gene ID】:4851 【Swiss Prot】:P46531
【Tested applications】:IHC
【Recommended dilution】:IHC 1:50-200.
【Immunogen】:A synthetic peptide of human NOTCH1
【Public Immunogen Range】:1750-1800/2555aa
【Storage】:Store at -20℃. Avoid freeze/thaw cycles.
Background:
Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4+ and CD8+ cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation.
Verified picture:
Immunohistochemistry of paraffin-embedded Human thyroid cancer with NOTCH1 antibody diluted at 1:100.