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Anti-TRIM24 Polyclonal Antibody
Cat: K111572P
Summary:
【Product name】:Anti-TRIM24 Polyclonal Antibody 【Source】:Rabbit
【Isotype】:IgG 【Purification】:Affinity purification
【Gene ID】:8805 【Swiss Prot】:O15164
【Tested applications】:IHC,WB
【Recommended dilution】:WB 1:1000-3000;IHC 1:100-300.
【Immunogen】:A synthetic peptide of human TRIM24
【Public Immunogen Range】:170-220/1050aa
【Storage】:Store at -20℃. Avoid freeze/thaw cycles.
Background:
Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity. Promotes ubiquitination and proteasomal degradation of p53/TP53. Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, including RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes (By similarity).
Verified picture:
Western blot analysis with TRIM24 antibody diluted at 1:2000;Lane: 293T,HeLa,L02,A549,PC-3M-IE8,C2C12,HEK293.
Immunohistochemistry of paraffin-embedded Human breast cancer with TRIM24 antibody diluted at 1:200.