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Anti-RAPGEF1 Polyclonal Antibody - SAlexa Fluor 633
Cat: K111587P - SAlexa Fluor 633
Summary:
【Product name】:Anti-RAPGEF1 Polyclonal Antibody - SAlexa Fluor 633 【Source】:Rabbit
【Isotype】:IgG 【Purification】:Affinity purification
【Gene ID】:2889 【Swiss Prot】:Q13905
【Tested applications】:IHC
【Recommended dilution】:IHC 1:100-300.
【Immunogen】:A synthetic peptide of human RAPGEF1
【Public Immunogen Range】:465-515/1077aa
【Storage】:Store at -20℃. Avoid freeze/thaw cycles.
Background:
Guanine nucleotide-releasing protein that binds to SH3 domain of CRK and GRB2/ASH. Transduces signals from CRK to activate RAS. Involved in cell branching and adhesion mediated by BCAR1-CRK-RAPGEF1 signaling and activation of RAP1. Plays a role in the establishment of basal endothelial barrier function. Plays a role in nerve growth factor (NGF)-induced sustained activation of Rap1 and neurite outgrowth.
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