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Anti-SGTA Polyclonal Antibody
Cat: K111650P
Summary:
【Product name】:Anti-SGTA Polyclonal Antibody 【Source】:Rabbit
【Isotype】:IgG 【Purification】:Affinity purification
【Gene ID】:6449 【Swiss Prot】:O43765
【Tested applications】:IHC,WB
【Recommended dilution】:WB 1:1000-3000;IHC 1:100-300.
【Immunogen】:Recombinant protein of human SGTA
【Public Immunogen Range】:1-314aa
【Storage】:Store at -20℃. Avoid freeze/thaw cycles.
Background:
Co-chaperone that binds misfolded and hydrophobic patches-containing client proteins in the cytosol. Mediates their targeting to the endoplasmic reticulum but also regulates their sorting to the proteasome when targeting fails (PubMed:28104892). Functions in tail-anchored/type II transmembrane proteins membrane insertion constituting with ASNA1 and the BAG6 complex a targeting module (PubMed:28104892). Functions upstream of the BAG6 complex and ASNA1, binding more rapidly the transmembrane domain of newly synthesized proteins (PubMed:28104892, PubMed:25535373). It is also involved in the regulation of the endoplasmic reticulum-associated misfolded protein catabolic process via its interaction with BAG6: collaborates with the BAG6 complex to maintain hydrophobic substrates in non-ubiquitinated states (PubMed:23129660, PubMed:25179605). Competes with RNF126 for interaction with BAG6, preventing the ubiquitination of client proteins associated with the BAG6 complex (PubMed:27193484). Binds directly to HSC70 and
Verified picture:
Western blot analysis with SGTA antibody diluted at 1:2000;Lane: K562,HepG2,Jurkat.
Immunohistochemistry of paraffin-embedded Human colorectal cancer with SGTA antibody diluted at 1:200.