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Anti-MEOX1 Polyclonal Antibody - SAlexa Fluor 750
Cat: K111683P - SAlexa Fluor 750
Summary:
【Product name】:Anti-MEOX1 Polyclonal Antibody - SAlexa Fluor 750 【Source】:Rabbit
【Isotype】:IgG 【Purification】:Affinity purification
【Gene ID】:4222 【Swiss Prot】:P50221
【Tested applications】:IHC,WB
【Recommended dilution】:WB 1:1000-3000;IHC 1:100-300.
【Immunogen】:Recombinant protein of human MEOX1
【Public Immunogen Range】:1-255aa
【Storage】:Store at -20℃. Avoid freeze/thaw cycles.
Background:
Mesodermal transcription factor that plays a key role in somitogenesis and is specifically required for sclerotome development. Required for maintenance of the sclerotome polarity and formation of the cranio-cervical joints (PubMed:23290072, PubMed:24073994). Binds specifically to the promoter of target genes and regulates their expression. Activates expression of NKX3-2 in the sclerotome. Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation. While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner. Required for hematopoietic stem cell (HSCs) induction via its role in somitogenesis: specification of HSCs occurs via the deployment of a specific endothelial precursor population, which arises within a sub-compartment of the somite named endotome.
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