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Anti-INS Polyclonal Antibody - Cy3
Cat: K111619P - Cy3
Summary:
【Product name】:Anti-INS Polyclonal Antibody - Cy3 【Source】:Rabbit
【Isotype】:IgG 【Purification】:Affinity purification
【Gene ID】:3630 【Swiss Prot】:P01308
【Tested applications】:ICC IF
【Recommended dilution】:ICC 1:50-200. IF 1:50-200
【Immunogen】:A synthetic peptide of human INS
【Public Immunogen Range】:60-110/110aa
【Storage】:Store at -20℃. Avoid freeze/thaw cycles.
Background:
After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]
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