下载
Anti-VEGFR1 Polyclonal Antibody
Cat: K009987P
Summary:
【Product name】:Anti-VEGFR1 Polyclonal Antibody 【Source】:Rabbit
【Isotype】:IgG 【Purification】:Affinity purification
【Gene ID】:2321 【Swiss Prot】:P17948
【Tested applications】:IHC,WB
【Recommended dilution】:WB 1:500-2000.IHC 1:50-100
【Immunogen】:Recombinant protein of human VEGFR1
【Public Immunogen Range】:20-300aa
【Storage】:Store at -20℃. Avoid freeze / thaw cycles.
Background:
This gene encodes a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine kinases (RTKs) which contain an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and a tyrosine kinase (TK) domain within the cytoplasmic domain. This protein binds to VEGFR-A, VEGFR-B and placental growth factor and plays an important role in angiogenesis and vasculogenesis. Expression of this receptor is found in vascular endothelial cells, placental trophoblast cells and peripheral blood monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Isoforms include a full-length transmembrane receptor isoform and shortened, soluble isoforms. The soluble isoforms are associated with the onset of pre-eclampsia.
Verified picture:
Immunohistochemistry of paraffin-embedded Human placenta with VEGFR1 antibody diluted at 1:100
Immunohistochemistry of paraffin-embedded rat spleen with VEGFR1 antibody diluted at 1:75.