Anti-GFER Polyclonal Antibody - RBITC
Cat: K111716P - RBITC
Summary:
| 【Product name】：Anti-GFER Polyclonal Antibody - RBITC | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：2671 | 【Swiss Prot】：P55789 |
| 【Tested applications】：WB ELISA IHC ICC IF | |
| 【Recommended dilution】：ICC 1:50-200. IF 1:50-200 | |
| 【Immunogen】：Recombinant protein of human GFER | |
| 【Public Immunogen Range】：1-125aa | |
| 【Storage】：Store at -20℃. Avoid freeze/thaw cycles. | |
Background:
Isoform 1:FAD-dependent sulfhydryl oxidase that regenerates the redox-active disulfide bonds in CHCHD4/MIA40, a chaperone essential for disulfide bond formation and protein folding in the mitochondrial intermembrane space. The reduced form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with GFER/ERV1, resulting in regeneration of the essential disulfide bonds in CHCHD4/MIA40, while GFER/ERV1 becomes re-oxidized by donating electrons to cytochrome c or molecular oxygen.6 Publications;Isoform 2:May act as an autocrine hepatotrophic growth factor promoting liver regeneration.
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