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Anti-IL17F Polyclonal Antibody - Cy3.5
Cat: K111737P - Cy3.5
Summary:
【Product name】:Anti-IL17F Polyclonal Antibody - Cy3.5 【Source】:Rabbit
【Isotype】:IgG 【Purification】:Affinity purification
【Gene ID】:112744 【Swiss Prot】:Q96PD4
【Tested applications】:IHC
【Recommended dilution】:IHC 1:100-300.
【Immunogen】:Recombinant protein of human IL17F
【Public Immunogen Range】:1-164aa
【Storage】:Store at -20℃. Avoid freeze/thaw cycles.
Background:
Effector cytokine of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity. IL17A-IL17F signals via IL17RA-IL17RC heterodimeric receptor complex, triggering homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter through SEFIR domains. This leads to downstream TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation. IL17A-IL17F is primarily involved in host defense against extracellular bacteria and fungi by inducing neutrophilic inflammation (By similarity). As signature effector cytokine of T-helper 17 cells (Th17), primarily induces neutrophil activation and recruitment at infection and inflammatory sites (By similarity). Stimulates the production of antimicrobial beta-defensins DEFB1, DEFB103A, and DEFB104A by mucosal epithelial cells, limiting the entry of m
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