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Anti-Phospho-STAT5-Y694 Polyclonal Antibody
Cat: K010001P
Summary:
【Product name】:Anti-Phospho-STAT5-Y694 Polyclonal Antibody 【Source】:Rabbit
【Isotype】:IgG 【Purification】:Affinity purification
【Gene ID】:6776/6777 【Swiss Prot】:P42229/P51692
【Tested applications】:IHC,WB
【Recommended dilution】:WB 1:100-500.IHC 1:100-200.
【Immunogen】:A phospho specific peptide corresponding to residues surrounding Y694 of human STAT5
【Storage】:Store at -20℃. Avoid freeze / thaw cycles.
Background:
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells. Alternatively spliced transcript variants have been found for this gene.
Verified picture:
Western blot analysis with Phospho-STAT5-Y694 antibody diluted at 1:2000;Lane:K562
Immunohistochemistry of paraffin-embedded Rat heart with Phospho-STAT5-Y694 antibody diluted at 1:100