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Anti-Phospho-PERK (Thr980) Polyclonal Antibody - SAlexa Fluor 350
Cat: K009730P - SAlexa Fluor 350
Summary:
【Product name】:Anti-Phospho-PERK (Thr980) Polyclonal Antibody - SAlexa Fluor 350 【Source】:Rabbit
【Isotype】:IgG 【Purification】:Affinity purification
【Gene ID】:13666 【Swiss Prot】:Q9Z2B5
【Tested applications】:ICC IF
【Recommended dilution】:ICC 1:50-200. IF 1:50-200
【Immunogen】:A synthetic peptide of mouse PERK around the phosphorylation site of Thr980
【Storage】:Store at -20℃. Avoid freeze / thaw cycles.
Background:
The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome. [provided by RefSeq, Jan 2010].
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