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Anti-NKX2-1 Polyclonal Antibody - Cy5
Cat: K111860P - Cy5
Summary:
【Product name】:Anti-NKX2-1 Polyclonal Antibody - Cy5 【Source】:Rabbit
【Isotype】:IgG 【Purification】:Octanoic acid-ammonium sulfate precipitation
【Gene ID】:7080 【Swiss Prot】:P43699
【Tested applications】:FC ICC IF
【Recommended dilution】:Flow-Cyt 1:50-200. ICC 1:50-200. IF 1:50-200
【Immunogen】:A synthetic peptide of human NKX2-1
【Public Immunogen Range】:15-65/371aa
【Storage】:Store at -20℃. Avoid freeze/thaw cycles.
Background:
Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis. Forms a regulatory loop with GRHL2 that coordinates lung epithelial cell morphogenesis and differentiation. Activates the transcription of GNRHR and plays a role in enhancing the circadian oscillation of its gene expression. Represses the transcription of the circadian transcriptional repressor NR1D1.
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