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Anti-USP15 Polyclonal Antibody - SAlexa Fluor 660
Cat: K111885P - SAlexa Fluor 660
Summary:
【Product name】:Anti-USP15 Polyclonal Antibody - SAlexa Fluor 660 【Source】:Rabbit
【Isotype】:IgG 【Purification】:Octanoic acid-ammonium sulfate precipitation
【Gene ID】:9958 【Swiss Prot】:Q9Y4E8
【Tested applications】:IHC,WB
【Recommended dilution】:WB 1:1000-3000.;IHC 1:100-300.
【Immunogen】:A synthetic peptide of human USP15
【Public Immunogen Range】:820-870/981aa
【Storage】:Store at -20℃. Avoid freeze/thaw cycles.
Background:
Hydrolase that removes conjugated ubiquitin from target proteins and regulates various pathways such as the TGF-beta receptor signaling, NF-kappa-B and RNF41/NRDP1-PRKN pathways. Acts as a key regulator of TGF-beta receptor signaling pathway, but the precise mechanism is still unclear: according to a report, acts by promoting deubiquitination of monoubiquitinated R-SMADs (SMAD1, SMAD2 and/or SMAD3), thereby alleviating inhibition of R-SMADs and promoting activation of TGF-beta target genes. According to another reports, regulates the TGF-beta receptor signaling pathway by mediating deubiquitination and stabilization of TGFBR1, leading to an enhanced TGF-beta signal. Able to mediate deubiquitination of monoubiquitinated substrates as well as 'Lys-48'-linked polyubiquitin chains, protecting them against proteasomal degradation. May also regulate gene expression and/or DNA repair through the deubiquitination of histone H2B. Acts as an inhibitor of mitophagy by counteracting the action of parkin (PRKN): hydrolyze
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