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Anti-PPP5C Polyclonal Antibody - HRP
Cat: K111990P - HRP
Summary:
【Product name】:Anti-PPP5C Polyclonal Antibody - HRP 【Source】:Rabbit
【Isotype】:IgG 【Purification】:Affinity purification
【Gene ID】:5536 【Swiss Prot】:P53041
【Tested applications】:WB,IHC
【Recommended dilution】:WB 1:500-2000. ELISA 1:100-1000. IHC 1:20-200. ICC 1:50-200
【Immunogen】:Recombinant protein of human PPP5C
【Public Immunogen Range】:1-350aa
【Storage】:Store at -20℃. Avoid freeze/thaw cycles.
Background:
Serine/threonine-protein phosphatase that dephosphorylates a myriad of proteins involved in different signaling pathways including the kinases CSNK1E, ASK1/MAP3K5, PRKDC and RAF1, the nuclear receptors NR3C1, PPARG, ESR1 and ESR2, SMAD proteins and TAU/MAPT. Implicated in wide ranging cellular processes, including apoptosis, differentiation, DNA damage response, cell survival, regulation of ion channels or circadian rhythms, in response to steroid and thyroid hormones, calcium, fatty acids, TGF-beta as well as oxidative and genotoxic stresses. Participates in the control of DNA damage response mechanisms such as checkpoint activation and DNA damage repair through, for instance, the regulation ATM/ATR-signaling and dephosphorylation of PRKDC and TP53BP1. Inhibits ASK1/MAP3K5-mediated apoptosis induced by oxidative stress. Plays a positive role in adipogenesis, mainly through the dephosphorylation and activation of PPARG transactivation function (By similarity). Also dephosphorylates and inhibits the anti-adipo
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