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Anti-ATIC Polyclonal Antibody - Cy3.5
Cat: K112006P - Cy3.5
Summary:
【Product name】:Anti-ATIC Polyclonal Antibody - Cy3.5 【Source】:Rabbit
【Isotype】:IgG 【Purification】:Affinity purification
【Gene ID】:471 【Swiss Prot】:P31939
【Tested applications】:IHC
【Recommended dilution】:IHC 1:100-300.
【Immunogen】:Recombinant protein of human ATIC
【Public Immunogen Range】:150-500aa
【Storage】:Store at -20℃. Avoid freeze/thaw cycles.
Background:
Bifunctional enzyme that catalyzes the last two steps of purine biosynthesis. Acts as a transformylase that incorporates a formyl group to the AMP analog AICAR (5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) to produce the intermediate formyl-AICAR (FAICAR). Can use both 10-formyldihydrofolate and 10-formyltetrahydrofolate as the formyl donor in this reaction. Also catalyzes the cyclization of FAICAR to IMP. Is able to convert thio-AICAR to 6-mercaptopurine ribonucleotide, an inhibitor of purine biosynthesis used in the treatment of human leukemias. Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization.
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