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Anti-ERLIN2 Polyclonal Antibody - SAlexa Fluor 660
Cat: K112035P - SAlexa Fluor 660
Summary:
【Product name】:Anti-ERLIN2 Polyclonal Antibody - SAlexa Fluor 660 【Source】:Rabbit
【Isotype】:IgG 【Purification】:Octanoic acid-ammonium sulfate precipitation
【Gene ID】:11160 【Swiss Prot】:O94905
【Tested applications】:IHC,WB
【Recommended dilution】:WB 1:1000-3000.; IHC 1:50-200.
【Immunogen】:Recombinant protein of human ERLIN2
【Public Immunogen Range】:1-153aa
【Storage】:Store at -20℃. Avoid freeze/thaw cycles.
Background:
Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs) such as ITPR1. Promotes sterol-accelerated ERAD of HMGCR probably implicating an AMFR/gp78-containing ubiquitin ligase complex. Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. May promote ER retention of the SCAP-SREBF complex.
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