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Anti-RNF166 Polyclonal Antibody - SAlexa Fluor 750
Cat: K112130P - SAlexa Fluor 750
Summary:
【Product name】:Anti-RNF166 Polyclonal Antibody - SAlexa Fluor 750 【Source】:Rabbit
【Isotype】:IgG 【Purification】:Affinity purification
【Gene ID】:115992 【Swiss Prot】:Q96A37
【Tested applications】:IHC
【Recommended dilution】:IHC 1:50-200.
【Immunogen】:Recombinant protein of human RNF166
【Public Immunogen Range】:1-238aa
【Storage】:Store at -20℃. Avoid freeze/thaw cycles.
Background:
E3 ubiquitin-protein ligase that promotes the ubiquitination of different substrates (PubMed:27880896).In turn, participates in different biological processes including interferon production or autophagy (PubMed:26456228, PubMed:27880896).Plays a role in the activation of RNA virus-induced interferon-beta production by promoting the ubiquitination of TRAF3 and TRAF6 (PubMed:26456228).Plays also a role in the early recruitment of autophagy adapters to bacteria (PubMed:27880896).Mediates 'Lys-29' and 'Lys-33'-linked ubiquitination of SQSTM1 leading to xenophagic targeting of bacteria and inhibition of their replication (PubMed:27880896).
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