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Anti-DNAJB12 Polyclonal Antibody - SAlexa Fluor 555
Cat: K112242P - SAlexa Fluor 555
Summary:
【Product name】:Anti-DNAJB12 Polyclonal Antibody - SAlexa Fluor 555 【Source】:Rabbit
【Isotype】:IgG 【Purification】:Affinity purification
【Gene ID】:54788 【Swiss Prot】:Q9NXW2
【Observed】:42kDa
【Tested applications】:ICC IF
【Recommended dilution】:ICC 1:50-200. IF 1:50-200
【Immunogen】:Recombinant protein of human DNAJB12
【Public Immunogen Range】:1-171aa
【Storage】:Store at -20℃. Avoid freeze / thaw cycles.
Background:
Acts as a co-chaperone with HSPA8/Hsc70; required to promote protein folding and trafficking, prevent aggregation of client proteins, and promote unfolded proteins to endoplasmic reticulum-associated degradation (ERAD) pathway (PubMed:21150129, PubMed:21148293).Acts by determining HSPA8/Hsc70's ATPase and polypeptide-binding activities (PubMed:21148293).Can also act independently of HSPA8/Hsc70: together with DNAJB14, acts as a chaperone that promotes maturation of potassium channels KCND2 and KCNH2 by stabilizing nascent channel subunits and assembling them into tetramers (PubMed:27916661).While stabilization of nascent channel proteins is dependent on HSPA8/Hsc70, the process of oligomerization of channel subunits is independent of HSPA8/Hsc70 (PubMed:27916661).When overexpressed, forms membranous structures together with DNAJB14 and HSPA8/Hsc70 within the nucleus; the role of these structures, named DJANGOs, is still unclear (PubMed:24732912).(Microbial infection) In case of infection by polyomavirus, invo
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