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Anti-PEG10 Polyclonal Antibody
Cat: K112303P
Summary:
【Product name】:Anti-PEG10 Polyclonal Antibody 【Source】:Rabbit
【Isotype】:IgG 【Purification】:Affinity purification
【Gene ID】:23089 【Swiss Prot】:Q86TG7
【Observed】:55/80kDa
【Tested applications】:WB
【Recommended dilution】:WB 1:1000-3000.
【Immunogen】:Recombinant protein of human PEG10
【Public Immunogen Range】:1-326aa
【Storage】:Store at -20℃. Avoid freeze / thaw cycles.
Background:
This is a paternally expressed imprinted gene that is thought to have been derived from the Ty3/Gypsy family of retrotransposons. It contains two overlapping open reading frames, RF1 and RF2, and expresses two proteins: a shorter, gag-like protein (with a CCHC-type zinc finger domain) from RF1; and a longer, gag/pol-like fusion protein (with an additional aspartic protease motif) from RF1/RF2 by -1 translational frameshifting (-1 FS). While -1 FS has been observed in RNA viruses and transposons in both prokaryotes and eukaryotes, this gene represents the first example of -1 FS in a eukaryotic cellular gene. This gene is highly conserved across mammalian species and retains the heptanucleotide (GGGAAAC) and pseudoknot elements required for -1 FS. It is expressed in adult and embryonic tissues (most notably in placenta) and reported to have a role in cell proliferation, differentiation and apoptosis. Overexpression of this gene has been associated with several malignancies, such as hepatocellular carcinoma and
Verified picture:
Western blot analysis with PEG10 antibody diluted at 1:2000;Lane: PC-3M-IE8,MCF7,U-251MG,HeLa.